Urticarial Rash in a Patient with Alpha-Gal Syndrome Caused by Subcutaneous Heparin at Prophylactic Dosing: A Case Report

Introduction: We report a patient with history of red meat allergy, or alpha-gal syndrome, who had an urticarial rash after exposure to unfractionated heparin at dose typically used for prophylaxis deep venous thrombosis. Although anaphylactic reactions have been reported systemic intravenous heparin, we believe this case is the first immunoglobulin E–mediated reaction subcutaneous prophylactic dosing.